Tratamiento de fallo ovárico prematuro
Premature ovarian failure (PFO) is a primary ovarian defect characterized by the absence of menarche (primary amenorrhea) or premature depletion of the ovarian follicles before age 40 (secondary amenorrhea). As in the case of physiological menopause, FOP is presented by typical manifestations of the...
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| Language: | Spanish |
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2021
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| Online Access: | https://dialnet.unirioja.es/servlet/oaiart?codigo=8056955 |
| Source: | RECIMUNDO: Revista Científica de la Investigación y el Conocimiento, ISSN 2588-073X, Vol. 5, Nº. 3, 2021, pags. 239-248 |
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RECIMUNDO: Revista Científica de la Investigación y el Conocimiento, ISSN 2588-073X, Vol. 5, Nº. 3, 2021, pags. 239-248
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| language |
Spanish
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| topic |
Fallo ovárico
infertilidad defecto ovárico defectos genéticos Ovarian failure infertility ovarian defect genetic defects |
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Fallo ovárico
infertilidad defecto ovárico defectos genéticos Ovarian failure infertility ovarian defect genetic defects Meza Miranda, Nelson Agustín Saltos Chica, María Gertrudis Álvarez Moreira, María Fernanda Navas López, José Francisco Tratamiento de fallo ovárico prematuro |
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Premature ovarian failure (PFO) is a primary ovarian defect characterized by the absence of menarche (primary amenorrhea) or premature depletion of the ovarian follicles before age 40 (secondary amenorrhea). As in the case of physiological menopause, FOP is presented by typical manifestations of the climacteric: infertility associated with palpitations, intolerance to heat, hot flashes, anxiety, depression, fatigue. This condition is biochemically characterized by low levels of gonadal hormones (estrogens and inhibins) and high levels of gonadotropins (LH and FSH) (hypergonadotropic amenorrhea). Beyond infertility, hormonal defects can cause serious neurological, metabolic or cardiovascular consequences and lead to the early onset of osteoporosis. The heterogeneity of FOP is also reflected in the variety of possible causes, including autoimmunity, toxic drugs, and genetic defects. This condition has a strong genetic component. X chromosome
abnormalities (eg, Turner syndrome) represent the leading cause of primary amenorrhea associated with ovarian dysgenesis. Despite the description of several candidate genes, the cause of FOP remains undetermined in the vast majority of cases. Management includes replacement of the hormonal defect with estrogen / progestin preparations. The only solution currently available for the fertility defect in women with absent follicular reserve is egg donation.
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| format |
Article
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| author |
Meza Miranda, Nelson Agustín
Saltos Chica, María Gertrudis Álvarez Moreira, María Fernanda Navas López, José Francisco |
| author_facet |
Meza Miranda, Nelson Agustín
Saltos Chica, María Gertrudis Álvarez Moreira, María Fernanda Navas López, José Francisco |
| author_sort |
Meza Miranda, Nelson Agustín
|
| title |
Tratamiento de fallo ovárico prematuro
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| title_short |
Tratamiento de fallo ovárico prematuro
|
| title_full |
Tratamiento de fallo ovárico prematuro
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| title_fullStr |
Tratamiento de fallo ovárico prematuro
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| title_full_unstemmed |
Tratamiento de fallo ovárico prematuro
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| title_sort |
tratamiento de fallo ovárico prematuro
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| publishDate |
2021
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https://dialnet.unirioja.es/servlet/oaiart?codigo=8056955
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1767463993144770560
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dialnet-ar-18-ART00014754412023-05-30Tratamiento de fallo ovárico prematuroMeza Miranda, Nelson AgustínSaltos Chica, María GertrudisÁlvarez Moreira, María FernandaNavas López, José FranciscoFallo ováricoinfertilidaddefecto ováricodefectos genéticosOvarian failureinfertilityovarian defectgenetic defectsPremature ovarian failure (PFO) is a primary ovarian defect characterized by the absence of menarche (primary amenorrhea) or premature depletion of the ovarian follicles before age 40 (secondary amenorrhea). As in the case of physiological menopause, FOP is presented by typical manifestations of the climacteric: infertility associated with palpitations, intolerance to heat, hot flashes, anxiety, depression, fatigue. This condition is biochemically characterized by low levels of gonadal hormones (estrogens and inhibins) and high levels of gonadotropins (LH and FSH) (hypergonadotropic amenorrhea). Beyond infertility, hormonal defects can cause serious neurological, metabolic or cardiovascular consequences and lead to the early onset of osteoporosis. The heterogeneity of FOP is also reflected in the variety of possible causes, including autoimmunity, toxic drugs, and genetic defects. This condition has a strong genetic component. X chromosome abnormalities (eg, Turner syndrome) represent the leading cause of primary amenorrhea associated with ovarian dysgenesis. Despite the description of several candidate genes, the cause of FOP remains undetermined in the vast majority of cases. Management includes replacement of the hormonal defect with estrogen / progestin preparations. The only solution currently available for the fertility defect in women with absent follicular reserve is egg donation.El fallo ovárico prematuro (FOP) es un defecto ovárico primario caracterizado por la ausencia de menarquia (amenorrea primaria) o agotamiento prematuro de los folículos ováricos antes de los 40 años (amenorrea secundaria). Como en el caso de menopausia fisiológica, FOP se presenta por manifestaciones típicas del climaterio: infertilidad asociado con palpitaciones, intolerancia al calor, sofocos, ansiedad, depresión, fatiga. Esta condición es bioquímicamente caracterizada por niveles bajos de hormonas gonadales (estrógenos e inhibinas) y altos niveles de gonadotropinas (LH y FSH) (amenorrea hipergonadotrópica). Más allá de la infertilidad, los defectos hormonales pueden causar graves consecuencias neurológicas, metabólicas o cardiovasculares y conducir a la aparición temprana de osteoporosis. La heterogeneidad de FOP también se refleja en la variedad de posibles causas, que incluyen autoinmunidad, fármacos tóxicos y defectos genéticos. Esta afección tiene un fuerte componente genético. Las anomalías del cromosoma X (por ejemplo, el síndrome de Turner) representan las principales causa de amenorrea primaria asociada con disgenesia ovárica. A pesar de la descripción de varios genes candidatos, la causa de FOP permanece indeterminada en la gran mayoría de los casos. El manejo incluye la sustitución del defecto hormonal por preparaciones de estrógeno / progestina. El La única solución actualmente disponible para el defecto de fertilidad en mujeres con reserva folicular ausente es donación de óvulos.2021text (article)application/pdfhttps://dialnet.unirioja.es/servlet/oaiart?codigo=8056955(Revista) ISSN 2588-073XRECIMUNDO: Revista Científica de la Investigación y el Conocimiento, ISSN 2588-073X, Vol. 5, Nº. 3, 2021, pags. 239-248spaLICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI
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