Tratamiento de fallo ovárico prematuro

Premature ovarian failure (PFO) is a primary ovarian defect characterized by the absence of menarche (primary amenorrhea) or premature depletion of the ovarian follicles before age 40 (secondary amenorrhea). As in the case of physiological menopause, FOP is presented by typical manifestations of the...

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Bibliographic Details
Main Authors: Meza Miranda, Nelson Agustín, Saltos Chica, María Gertrudis, Álvarez Moreira, María Fernanda, Navas López, José Francisco
Format: Article
Language:Spanish
Published: 2021
Subjects:
Fallo ovárico
infertilidad
defecto ovárico
defectos genéticos
Ovarian failure
infertility
ovarian defect
genetic defects
Online Access:https://dialnet.unirioja.es/servlet/oaiart?codigo=8056955
Source:RECIMUNDO: Revista Científica de la Investigación y el Conocimiento, ISSN 2588-073X, Vol. 5, Nº. 3, 2021, pags. 239-248
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Tratamiento de fallo ovárico prematuro
Summary: Premature ovarian failure (PFO) is a primary ovarian defect characterized by the absence of menarche (primary amenorrhea) or premature depletion of the ovarian follicles before age 40 (secondary amenorrhea). As in the case of physiological menopause, FOP is presented by typical manifestations of the climacteric: infertility associated with palpitations, intolerance to heat, hot flashes, anxiety, depression, fatigue. This condition is biochemically characterized by low levels of gonadal hormones (estrogens and inhibins) and high levels of gonadotropins (LH and FSH) (hypergonadotropic amenorrhea). Beyond infertility, hormonal defects can cause serious neurological, metabolic or cardiovascular consequences and lead to the early onset of osteoporosis. The heterogeneity of FOP is also reflected in the variety of possible causes, including autoimmunity, toxic drugs, and genetic defects. This condition has a strong genetic component. X chromosome abnormalities (eg, Turner syndrome) represent the leading cause of primary amenorrhea associated with ovarian dysgenesis. Despite the description of several candidate genes, the cause of FOP remains undetermined in the vast majority of cases. Management includes replacement of the hormonal defect with estrogen / progestin preparations. The only solution currently available for the fertility defect in women with absent follicular reserve is egg donation.

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