Uso del Tratamiento Biológico en pacientes con Psoriasis
Psoriasis is a chronic erythematous scaly disease of the skin, characterized by excessive hyperproliferation of epidermal keratinocytes and infiltration of the skin by inflammatory cells. Its cause is multifactorial: genetic predisposition triggered by an environmental stimulus, it is associated wit...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://dialnet.unirioja.es/servlet/oaiart?codigo=8603936 |
| Source: | RECIMUNDO: Revista Científica de la Investigación y el Conocimiento, ISSN 2588-073X, Vol. 6, Nº. 4, 2022, pags. 26-35 |
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| Summary: |
Psoriasis is a chronic erythematous scaly disease of the skin, characterized by excessive hyperproliferation of epidermal keratinocytes and infiltration of the skin by inflammatory cells. Its cause is multifactorial: genetic predisposition triggered by an environmental stimulus, it is associated with other inflammatory diseases such as arthritis, inflammatory bowel disease and HIV infection. Biological treatments are indicated in the treatment of adult patients with moderate to severe psoriasis, patients with localized diseases, involving sites of high emotional impact such as: genitals, hands, feet, head and neck where it has a high functional and/or psychosocial impact. . Patients who previously received classical systemic treatment, including phototherapy, and who currently do not respond, have it contraindicated. Psori-asis treatment has evolved with the advent of biologic therapies, including infliximab, etanercept, adalimumab, efalizumab, and alefacept. These drugs are designed to counteract specific components of the immune system, they are a major technological advance over tradi-tional immunosuppressive drugs and HIV infection. Biologic therapy is the use of agents that can specifically target an immune or genetic mediator of a pathophysiologic process. The introduction of these biological therapies has greatly improved the treatment of psoriasis. Biological agents interrupt the activation and migration of T cells. All with well-known adverse effects that require clinical and paraclinical monitoring. Therefore, to reduce the toxicity and side effects of treatment, rotational or sequential therapy between the different drugs is recommended. In search of an effective therapeutic alternative with a better safety profile than traditional immunosuppressive agents, since they involve a specific part of the immune system. A descriptive methodology was applied, with a documentary approach, that is, reviewing sources available on the network, with timely and relevant content to respond to what is discussed in this article |
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