Farmacología del amlodipino
Amlodipine is a calcium antagonist, of the dihydropyridine family, and its main function is to inhibit the entry of calcium ions through the cell membranes of cardiac and vascular smooth muscle. The methodology used for this research work is framed within a bibliographic review of documentary type,...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://dialnet.unirioja.es/servlet/oaiart?codigo=8410267 |
| Source: | RECIMUNDO: Revista Científica de la Investigación y el Conocimiento, ISSN 2588-073X, Vol. 6, Nº. 2, 2022, pags. 374-380 |
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| Summary: |
Amlodipine is a calcium antagonist, of the dihydropyridine family, and its main function is to inhibit the entry of calcium ions through the cell membranes of cardiac and vascular smooth muscle. The methodology used for this research work is framed within a bibliographic review of documentary type, since we are going to deal with issues raised at a theoretical level such as Pharmacology of amlodipine. The technique for data collection is made up of electronic materials, the latter such as Google Scholar, PubMed, among others, relying on the use of descriptors in health sciences or MESH terminology. The information obtained here will be reviewed for further analysis. Amlodipine is a calcium antagonist with extensive clinical advantages and pharmacokinetic properties, which is classified within the group of dihydropyridines, has the particularity of delaying Cmax, which generates few adverse reactions because vasodilation does not occur as fast as other drugs from the same group. Its elimination within the body has a long half-life of approximately 40 hours and this is due to its volume of distribution capacity and its slow hepatic clearance, which allows a single daily administration, achieving greater therapeutic compliance for the patient. Apart from what has been described above, it can be combined with other antihypertensive drugs, enhancing the hypotensive effect of diuretics, beta-blockers, angiotensin-converting enzyme inhibitors (ACEI) and alpha-blockers. |
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