Amiloidosis cutánea primaria
Primary localized cutaneous amyloidosis (PLCA) is a relatively rare RC condition characterized by amyloid deposition in the dermis without associated deposits in internal organs. Histopathology of cutaneous amyloidosis by hematoxylin and eosin (H&E) staining shows eosinophilic hyaline material i...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://dialnet.unirioja.es/servlet/oaiart?codigo=8410263 |
| Source: | RECIMUNDO: Revista Científica de la Investigación y el Conocimiento, ISSN 2588-073X, Vol. 6, Nº. 2, 2022, pags. 330-337 |
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| Summary: |
Primary localized cutaneous amyloidosis (PLCA) is a relatively rare RC condition characterized by amyloid deposition in the dermis without associated deposits in internal organs. Histopathology of cutaneous amyloidosis by hematoxylin and eosin (H&E) staining shows eosinophilic hyaline material in the papillary dermis, which can be further confirmed by Congo red (CR) staining, direct immunofluorescence test (DIF), or direct immunofluorescence (DIF). immunohistochemistry. Rapid and accurate diagnosis of primary cutaneous amyloidosis (PCA) can be difficult because its symptoms are often subtle and nonspecific. RC and IFD staining complement each other for the detection of macular amyloidosis. For lichen and biphasic amyloidosis, both CR and IFD are comparable modalities. DAPI staining could serve as a useful technique for establishing the diagnosis of ACLP, and its high efficac in diagnosing ACLP makes it less dependent on the experience levels of the evaluators. Furthermore, the binding of DAPI to the AT-rich sequence of double-stranded DNA suggests that
amyloid may contain similarly structured DNA or nucleic acid. |
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