Síndrome de Huntington: revisión bibliográfica y actualización

Huntington is a rare neurodegenerative disorder in our society, which affects the central nervous system (CNS) and is char-acterized by dementia, psychiatric and behavioral disorders and involuntary movements (Huntington's chorea). It mostly affects patients with white skin and the approximate...

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Bibliographic Details
Main Authors: Vallejo Zambrano, Cristhian Rubén, Steinzappir Navia, Mendel Arnaldo, Ávila Meza, Simón Alfonso, Azua Zambrano, María Cristina, Zambrano Vásquez, Karla B., Chumo Rivero, Miguel Eduardo
Format: Article
Language:Spanish
Published: 2020
Subjects:
Huntington
Autosómico
Determinación
Tratamiento
Autosomal
Determination
Treatment
Determinação
Tratamento
Online Access:https://dialnet.unirioja.es/servlet/oaiart?codigo=7999179
Source:RECIMUNDO: Revista Científica de la Investigación y el Conocimiento, ISSN 2588-073X, Vol. 4, Nº. 4, 2020, pags. 392-398
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Síndrome de Huntington: revisión bibliográfica y actualización
Summary: Huntington is a rare neurodegenerative disorder in our society, which affects the central nervous system (CNS) and is char-acterized by dementia, psychiatric and behavioral disorders and involuntary movements (Huntington's chorea). It mostly affects patients with white skin and the approximate age of onset is between 30-50 years; however, there may be cases where it begins at age 20 (juvenile Huntington's disease). Huntington syndrome (HS) is an autosomal dominant inherited disease, caused by a repeated elongation of the CAG on chromosome 4, in the Huntingtine gene. For its diagnosis, we rely on clinical signs and symptoms and confirm it with a DNA determination. Prenatal diagnosis is possible by amniocentesis. We must bear in mind that, although there is no cure for this disease, there are treatments that improve the quality of life of affected patients. The objective of this study is to consolidate current theories associated with HS. This review was pre-pared through a careful analysis of indexed computer articles in medical information sources: Pubmed, Medline, Pubmed Central; being a bibliographic documentary study. It is vitally important to have a study regarding this disease, in which the pathophysiology can be understood in a precise way; to later, give a good symptomatological treatment to patients with HS.

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