Reinfeccion de COVID-19: Respuesta inmune y posibles causas
The bibliographic review was carried out with published articles related to the topic with case reports or case series in the search platforms COCHRANE, PUBMED, ELSEVIER.The new virus (SARS-CoV-2) constitutes a current global health problem due to its rapid spread and impact on health ser-vices and...
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| Format: | Article |
| Language: | Spanish |
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2020
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| Online Access: | https://dialnet.unirioja.es/servlet/oaiart?codigo=7999190 |
| Source: | RECIMUNDO: Revista Científica de la Investigación y el Conocimiento, ISSN 2588-073X, Vol. 4, Nº. 4, 2020 (Ejemplar dedicado a: Noviembre (Especial)), pags. 92-100 |
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The bibliographic review was carried out with published articles related to the topic with case reports or case series in the search platforms COCHRANE, PUBMED, ELSEVIER.The new virus (SARS-CoV-2) constitutes a current global health problem due to its rapid spread and impact on health ser-vices and at the socioeconomic level; The scientists' efforts are focused on finding a possible vaccine with little research time.In the current virus, 103 genomes have been discovered, which are distinguished in different strains that could evolve. In most cases its involvement is mild due to the immune response mediated mainly by T lymphocytes (CD4 +) and (CD8 +) with subsequent antibody formation and immune protection memory.However, report of isolated cases and series of cases in which an apparent reinfection is evidenced; that is, the appear-ance of signs, symptoms, the presence of viruses in the detection tests, casts doubt on whether there is immunological protection after viral infection or possible vaccines. The appearance of the first reported and confirmed case of reinfection proposes a new and more extensive investigation on the subject.There are different alterations in the immune response that can cause or contribute to a possible reinfection: genomic vari-ety, immune status of the host and its response, immunosuppression factors, infection by a new viral strain or evolution of the viral strain, false positives due to poorly processed samples, different respiratory virus infections, SARS-CoV-2 evasion mechanisms to the immune response. |
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